Science, by its very nature, transcends borders. Scientific revolutions arise from cross-border collaborations, exchanges of talent, and shared infrastructures. Europe is the appropriate, indeed imperative, arena. The Paris-Saclay Call embodies this collective effort: sharing risks, expertise, and tools to build a technically independent and globally influential Union over the long term.

France Universités welcomes the Call of Paris-Saclay’s commitment to academic freedom, European values, and the recognition of a fifth freedom — the free circulation of knowledge, research, and education.

Cooperation must foster a shared European space where these principles are not only protected but actively advanced. The goal is to strengthen, not complicate, existing national instruments. The European research area should stand as a collective commitment to a knowledge system that serves society as a whole.

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We must safeguard academic freedom and strengthen European university alliances. Scientific excellence is a magnet for global talent that identifies with and upholds Europe’s values of openness, freedom, and knowledge.

Rooted in its territory and closely connected to academic and industrial ecosystems in France and internationally, the CEA actively contributes to the global reach of science across a continuum ranging from the most fundamental research to technology transfer. This unwavering commitment aims to support French and European scientific, technological, and industrial competitiveness and sovereignty, while upholding the freedom to conduct research, to innovate, and to take initiative in order to meet the expectations of the State and of society as a whole.

Science is built on continuous, borderless exchange and sharing, and Europe is the right scale to address global challenges. For these reasons, the CEA supports the Call of Paris-Saclay.

Ifremer’s activities lie at the intersection of two major commons: science and the ocean. The European Union constitutes the world’s leading maritime space. Ifremer therefore joins the Call of Paris-Saclay to affirm its strong commitment to the freedom and independence of research, from its most fundamental aspects to its applications serving ocean protection, the blue economy, and maritime public policies, and to underline how essential the European scale is to addressing the related scientific challenges.

In the face of climatic, health, and economic shocks, we need scientists to understand their impacts and to build transition scenarios for agriculture, food systems, and forests. Consortia bringing together stakeholders and research communities will enable the development of solutions to support these transitions. The European Union is the relevant scale to mobilize such responses. For these reasons, we support the Call of Paris-Saclay.

It is essential to align national, European, and international strategies. The Digital Services Act (DSA), the Digital Markets Act (DMA), and the Cyber Resilience Act must be closely coordinated with our research agendas to ensure seamless digital sovereignty. In this perspective, we support the Call of Paris-Saclay.

By joining the Call of Paris-Saclay, on behalf of Inserm, we affirm our conviction that the European scale is crucial for innovative, strong, and ambitious research, and particularly in biomedical research, for science serving the health of all.

European sovereignty is not decreed — it is built. It relies on free, rigorous, and independent research capable of generating the knowledge and technologies that will shape tomorrow’s Europe. The Call of Paris-Saclay reminds us of what matters most: investing together, pooling our strengths, and cooperating to make science not only a driver of innovation, but a genuine political lever in service of our shared future.

Fundamental research transforms society, particularly in the field of health. Twenty‑four of today’s twenty‑eight major drugs are the result of 15 to 20 years of fundamental research. Defending science is defending democracy. For these reasons, we support the Call of Paris-Saclay.

Faced with multiplying health crises, Europe can no longer afford to depend on other powers for its health security. Preparing for future pandemics requires an integrated European vision in which fundamental research, innovation, and public health form an inseparable whole. The Institut Pasteur, drawing on its unique model combining scientific excellence, independence, and an international network, strongly advocates for a truly ambitious FP10 framework programme.

The time for half measures is over: our collective ability to protect our populations and to compete globally in science is being decided now. For these reasons, we support the Call of Paris-Saclay.

Knowledge and science form the foundation of our sovereignty and competitiveness for the future. They are also our best assets for addressing the major challenges of our time. In this respect, Europe acts as an accelerator, enabling national research strategies to flourish in harmony and to jointly address the challenges of innovation in service of the common good. For these reasons, we support the Call of Paris-Saclay.

As a deeply committed actor in research and innovation for health through nutrition, Danone fully supports the Call of Paris-Saclay. In line with our European partnerships and public–private collaborations, we reaffirm our ambition to promote open, rigorous research aligned with the needs of today’s and tomorrow’s societies..

EDF considers the decarbonization of the economy, through the electrification of both domestic and industrial uses, as a key instrument for both European sovereignty and economic development. Innovation in these areas is a powerful driver of growth at the heart of EDF’s R&D DNA. A European and collaborative approach to R&D is essential to achieve the critical mass needed to accelerate the deployment of shared innovative technologies. For these reasons, EDF supports the Call of Paris-Saclay.

Equans, a key player in energy and services firmly established in Europe, is proud to help transform scientific excellence into innovation by facilitating the transition from R&D to concrete implementation. Thanks to the expertise of its teams across nine of the twelve areas covered by the Call of Paris-Saclay, we foster the emergence of a high‑performing and sustainable technological ecosystem.

Sanofi supports the Call of Paris-Saclay for a more ambitious Europe. Investing massively in science means ensuring our health sovereignty, industrial competitiveness, and our capacity to address public health challenges. The European scale is indispensable.

Sovereignty means strengthening our complementarities and our cooperation. Together, we are stronger in continuing to push the boundaries of excellence in research and innovative applications. For these reasons, STMicroelectronics supports the Call of Paris-Saclay.